Drug-Drug Interaction Networks:

• Drug-Drug Interaction: Drotrecogin alfa interacts with Clopidogrel
• Drug-Drug Interaction Description: Antiplatelet agents such as clopidogrel may enhance the adverse/toxic effect of Drotrecogin Alfa. Bleeding may occur. Increase monitoring for signs/symptoms of bleeding during concomitant therapy. If possible, avoid use of drotrecogin within 7 days of use of any IIb/IIIa antagonists, higher dose aspirin (more than 650 mg/day), or use of other antiplatelet agents.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB00758
• Interacting Drug Name: Clopidogrel
• Drug : DB00758 Clopidogrel Clopidogrel []



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Dalteparin
• Drug-Drug Interaction Description: Low molecular weight heparin (LMWH) such as dalteparin may enhance the adverse/toxic effect of drotrecogin alfa. Bleeding may occur.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB06779
• Interacting Drug Name: Dalteparin
• Drug : DB06779 Dalteparin ['Daltepariininatrium', u'Dalteparin sodn\xe1 s\u016fl', 'Dalteparin Sodyum', u'Dalteparin-n\xe1trium', u'Dalteparina s\xf3dica', u'Dalt\xe9parine sodique', 'Dalteparinnatrium', 'Dalteparino natrio druska', 'Dalteparinum Natricum', 'Dalteparyna sodowa', 'Heparin Fragment KABI 2165', 'Kabi-2165', 'Tedelparin Sodium']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Enoxaparin
• Drug-Drug Interaction Description: Combination should be used with caution after weighing advantages and disadvantages. Low molecular weight heparins such as enoxaparin may increase the adverse effects of drotrecogin. Monitor for bleeding if used concomitantly.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB01225
• Interacting Drug Name: Enoxaparin
• Drug : DB01225 Enoxaparin Enoxaparin ['LMWH', 'Low Molecular Weight Heparin']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Fondaparinux sodium
• Drug-Drug Interaction Description: Drotrecogin alfa may increase the adverse effects of fondaparinux, resulting in excessive bleeding. Concomitant use should be avoided.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB00569
• Interacting Drug Name: Fondaparinux sodium
• Drug : DB00569 Fondaparinux sodium Fondaparinux sodium ['Arixtra']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Heparin
• Drug-Drug Interaction Description: The potential benefits of drotrecogin alfa should be weighed against an increased risk of bleeding in patients receiving therapeutic doses of heparin. Monitor for bleeding during concomitant therapy, and immediately stop infusion of drotrecogin if clinically important bleeding occurs. In patients receiving prophylactic heparin doses, consider continuing this during drotrecogin.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB01109
• Interacting Drug Name: Heparin
• Drug : DB01109 Heparin Heparin ['Alpha-Heparin', 'Heparin sodium', 'Heparin sodium preservative Free', 'Heparin sodium salt', 'Heparin sulfate', 'Heparinate', 'Heparinic acid', 'Sodium heparin']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Ketoprofen
• Drug-Drug Interaction Description: The antiplatelet effect of ketoprofen may increase the bleed risk associated with drotrecogin alfa. Consider spacing use of the two agents by at least 7 days. Increase monitoring for signs and symptoms of bleeding during concomitant therapy.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB01009
• Interacting Drug Name: Ketoprofen
• Drug : DB01009 Ketoprofen Ketoprofen ['m-Benzoylhydratropic acid']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Nadroparin
• Drug-Drug Interaction Description: The potential benefits of drotrecogin alfa should be weighed against an increased risk of bleeding in patients receiving therapeutic doses of low molecular weight heparins such as nadroparin. Monitor for bleeding during concomitant therapy, and immediately stop infusion of drotrecogin if clinically important bleeding occurs. In patients receiving prophylactic heparin doses, consider continuing this during drotrecogin.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB08813
• Interacting Drug Name: Nadroparin
• Drug : DB08813 Nadroparin []



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Tenecteplase
• Drug-Drug Interaction Description: Increased risk of bleeding.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB00031
• Interacting Drug Name: Tenecteplase
• Drug : DB00031 Tenecteplase ['t- PA', 't-plasminogen activator', 'Tissue-type plasminogen activator precursor', 'tPA']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Tinzaparin
• Drug-Drug Interaction Description: Low molecular weight heparins (LMWHs) such as tinzaparin may enhance the adverse/toxic effects of drotrecogin alfa. Bleeding may occur. The potential benefits of drotrecogin alfa should be weighed against the increased risk of bleeding in patients on therapeutic doses of LMWHs.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB06822
• Interacting Drug Name: Tinzaparin
• Drug : DB06822 Tinzaparin []



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Tolmetin
• Drug-Drug Interaction Description: Increased risk of bleeding. Monitor for increased bleeding during concomitant therapy.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB00500
• Interacting Drug Name: Tolmetin
• Drug : DB00500 Tolmetin Tolmetin ['Tolmetin Sodium', 'Tolmetina [DCIT]', 'Tolmetine [INN-French]', 'Tolmetino [INN-Spanish]', 'Tolmetinum [INN-Latin]']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Treprostinil
• Drug-Drug Interaction Description: The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Drotrecogin alfa. Monitor for increased bleeding during concomitant thearpy.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB00374
• Interacting Drug Name: Treprostinil
• Drug : DB00374 Treprostinil Treprostinil []



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Urokinase
• Drug-Drug Interaction Description: Increased risk of bleeding.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB00013
• Interacting Drug Name: Urokinase
• Drug : DB00013 Urokinase ['U-plasminogen activator', 'uPA', 'Urokinase-type plasminogen activator precursor']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Vilazodone
• Drug-Drug Interaction Description: Increase monitoring for signs/symptoms of bleeding during concomitant therapy. If possible, avoid use of drotrecogin within 7 days of use of any IIb/IIIa antagonists, higher dose aspirin (more than 650 mg/day), or use of other antiplatelet agents.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB06684
• Interacting Drug Name: Vilazodone
• Drug : DB06684 Vilazodone Vilazodone ['EMD-68843', 'SB 659746A']



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• Drug-Drug Interaction: Drotrecogin alfa interacts with Warfarin
• Drug-Drug Interaction Description: Increased risk of bleeding.
• First Drug ID: DB00055
• Drug Name: Drotrecogin alfa
• Drug : DB00055 Drotrecogin alfa ['Anticoagulant protein C', 'Autoprothrombin IIA', 'Blood coagulation factor XIV', 'Vitamin K-dependent protein C precursor']



• Second Drug ID: DB00682
• Interacting Drug Name: Warfarin
• Drug : DB00682 Warfarin Warfarin ['Warfarin sodium']



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